Segmental bone defects: Mesoblast - the adult stem cell company. Regeneration of adult stem cells for regrowth of bone and cartilage.

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Segmental bone defects
More than one million of the 5.6 million fractures occurring annually in the United States (US) are associated with healing difficulties in which repair processes stop before the break is completely repaired. Problems can occur due to ineffective immobilisation of the broken bone, disruption to the blood supply or infection.

Up to 10 per cent of fractures that heal poorly require bone grafting using either the patient's own bone tissue or that from a donor.

Bone grafting is not a straightforward process. It is greatly limited by a lack of blood supply to the new bone and by the limited number of regenerating bone cells in the grafted tissue.

Other disadvantages of bone grafting are the chronic pain at the donor site where the patient's own bone is used, and the problem of immune rejection where bone is obtained from a donor.

Mesoblast's MPC technology can generate both new bone and new blood vessels, enabling greater bone regeneration. There will be no immune reaction and no donor site, so no chronic pain. Implantation of MPC at the site of poorly-healing fractures is likely to be more effective in less time, while eliminating other complications of bone grafting.

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